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Are GLP-1 medications like Ozempic safe during pregnancy?

Last updated on April 9, 2026

Current evidence and medical consensus recommend stopping GLP-1 medications (like Ozempic or Wegovy) before becoming pregnant and not using them during pregnancy. Animal studies suggest possible fetal risk, but human data is extremely limited and the situation is rapidly evolving.

Evidence Summary

  • Data source: Animal teratogenicity studies; limited human observational data; FDA labeling; emerging registry data

  • Key finding: Animal studies show embryo-fetal toxicity at doses comparable to human therapeutic levels — a meaningful caution signal

  • Key finding: GLP-1s are not recommended during pregnancy by FDA and most ob-gyn societies; human safety data is extremely limited

  • Key finding: Weight loss before pregnancy (aided by GLP-1s) may improve fertility and pregnancy outcomes — the benefit is in pre-conception use

  • Caveat: This is a rapidly evolving field; registry data from accidental exposures during early pregnancy is being collected and will clarify real-world risk

Confidence: Low-to-moderate confidence — animal data is concerning but human pregnacy data is much more reassuring; guidance is precautionary by necessity.

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